Aquaporin-4 knockdown ameliorates hypoxic-ischemic cerebral edema in newborn piglets
نویسندگان
چکیده
منابع مشابه
Goreisan Inhibits Upregulation of Aquaporin 4 and Formation of Cerebral Edema in the Rat Model of Juvenile Hypoxic-Ischemic Encephalopathy
Secondary cerebral edema regulation is of prognostic significance in hypoxic-ischemic encephalopathy (HIE), and aquaporin 4 (AQP4) plays an important role in the pathogenesis of cerebral edema. The traditional Japanese herbal medicine Goreisan relieves brain edema in adults; however, its effect and pharmacological mechanism in children are unknown. We investigated the effects of Goreisan on HIE...
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Brain edema after hypoxic-ischemic brain damage (HIBD) is a serious problem in neonates. Mannitol can mitigate edema; however, the molecular mechanism has not been fully elucidated. It has been reported that aquaporin-4 (AQP4), a member of the water channel protein family, plays a vital role in the development of brain edema. We therefore investigated whether mannitol might alleviate brain edem...
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Cerebral ischemic stroke, which affects the global population, is a major disease with high incidence, mortality, and disability. Accumulating evidence has indicated that abnormal microRNA (miRNA) expression plays essential roles in the pathologies of ischemic stroke. Yet, the underlying regulatory mechanism of miRNAs in cerebral ischemic stroke remains unclear. We investigated the role of miR-...
متن کاملThe time course changes in expression of aquaporin 4 and aquaporin 1 following global cerebral ischemic edema in rat
BACKGROUND The aim of this global cerebral ischemia study was to study the changes in expression levels of aquaporin 4 (AQP4) and AQP1 over time. METHODS Sprague-Dawley type male rats were divided into six groups. Sham group and ischemia/reperfusion were performed on five other groups using the four-vessel occlusion model. Reperfusion was done 30 min after the occlusion, and each group was te...
متن کاملAquaporin-4: A Potential Therapeutic Target for Cerebral Edema
Aquaporin-4 (AQP4) is a family member of water-channel proteins and is dominantly expressed in the foot process of glial cells surrounding capillaries. The predominant expression at the boundaries between cerebral parenchyma and major fluid compartments suggests the function of aquaporin-4 in water transfer into and out of the brain parenchyma. Accumulating evidences have suggested that the dys...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2015
ISSN: 1521-6543
DOI: 10.1002/iub.1356